Notched graphite polymimide composites at room and notched graphite polymide composites at room and elevated temperatures

The fracture behavior in graphite/polyimide (Gr/PI) Celion 6000/PMR-15 composites was characterized. Emphasis was placed on the correlation between the observed failure modes and the deformation characteristics of center-notched Gr/Pl laminates. Crack tip damage growth, fracture strength and notch sensitivity, and the associated characterization methods were also examined. Special attention was given to nondestructive evaluation of internal damage and damage growth, techniques such as acoustic emission, X-ray radiography, and ultrasonic C-scan. Microstructural studies using scanning electron microscopy, photomicrography, and the pulsed nuclear magnetic resonance technique were employed as well. All experimental procedures and techniques are described and a summary of representative results for Gr/Pl laminates is given

L-DART: A Penetrator Mission for Lunar Permanently Shadowed Regions

Lunar Direct Analysis of Resource Traps (L‐DART) will address many current knowledge gaps concerning lunar volatiles and permanently shadowed regions (PSRs), providing in-situ ground truth data to calibrate numerous existing remote datasets. It builds on UK expertise in developing and testing penetrator system concepts for the Moon and Europa (e.g. MOONLITE). Following release of a Penetrator Descent Module in lunar orbit (Figure 1), its Penetrator Delivery System performs de-orbit and orientation before releasing the instrumented Penetrator to penetrate a few meters into target lunar surface at ~300 m/s. The penetrator itself serves as the sampling tool and an on-board mass spectrometer analyses in-situ the volatiles released both in the impact and in the subsequent thermal soak from lander to surrounding regolith. A pair of 3‐axis accelerometers measure regolith structure during the landing event and constrain penetrator final location. Temperature sensors enable regolith thermal properties to be deduced. Pre-and post impact imagery is obtained for context. Science is complete and data relayed to Earth within 1-2 hours, minimizing system mass and lifetime requirements. Possible landing sites include Cabeus (for comparison with LCROSS) or Shoemaker which exhibits excess hydrogen, or areas indicated by LRO to exhibit putative surface frost. Alternatively, L‐DART could target the hypothesised ancient (paleo) south pole and hence potentially ancient volatiles

Tikhonov adaptively regularized gamma variate fitting to assess plasma clearance of inert renal markers

The Tk-GV model fits Gamma Variates (GV) to data by Tikhonov regularization (Tk) with shrinkage constant, λ, chosen to minimize the relative error in plasma clearance, CL (ml/min). Using 169Yb-DTPA and 99mTc-DTPA (n = 46, 8–9 samples, 5–240 min) bolus-dilution curves, results were obtained for fit methods: (1) Ordinary Least Squares (OLS) one and two exponential term (E1 and E2), (2) OLS-GV and (3) Tk-GV. Four tests examined the fit results for: (1) physicality of ranges of model parameters, (2) effects on parameter values when different data subsets are fit, (3) characterization of residuals, and (4) extrapolative error and agreement with published correction factors. Test 1 showed physical Tk-GV results, where OLS-GV fits sometimes-produced nonphysical CL. Test 2 showed the Tk-GV model produced good results with 4 or more samples drawn between 10 and 240 min. Test 3 showed that E1 and E2 failed goodness-of-fit testing whereas GV fits for t > 20 min were acceptably good. Test 4 showed CLTk-GV clearance values agreed with published CL corrections with the general result that CLE1 > CLE2 > CLTk-GV and finally that CLTk-GV were considerably more robust, precise and accurate than CLE2, and should replace the use of CLE2 for these renal markers

Giambattista Vico and the wisdom of teaching

This paper offers a rehabilitation of the neglected eighteenth-century thinker and philosopher, Giambattista Vico (1668–1744), and defends the contemporary relevance of his construction of the wisdom of teaching. Reinventing the ancient traditions of European rhetoric, and reacting with great critical hostility to the pervasive educational influence of the thought and methods of Rene Descartes and his followers in the Jansenist movement, Vico’s major writings and public lectures sought to articulate a complete philosophy of education quite at variance with the styles of rationality and pedagogy favoured in the European Enlightenment. In his insistence on the key function of poetics, narrative, myth, religion, shared common sense, emotion, belonging and ritual in the formation of the educated person, Vico laid stress upon the role of the imagination and its nurture in the development of a properly enlarged and sympathetic rationality. With the implications for teaching methods, curriculum and the understanding and protection of the unique capacities of childhood, Vico has much to offer the philosophy and practice of modern education as it faces the multiple allures of hyperationality and the attenuated knowledge-economy account of its central aims and purposes

Plasticity in Intrinsic Excitability of Hypothalamic Magnocellular Neurosecretory Neurons in Late-Pregnant and Lactating Rats

Oxytocin and vasopressin secretion from the posterior pituitary gland are required for normal pregnancy and lactation. Oxytocin secretion is relatively low and constant under basal conditions but becomes pulsatile during birth and lactation to stimulate episodic contraction of the uterus for delivery of the fetus and milk ejection during suckling. Vasopressin secretion is maintained in pregnancy and lactation despite reduced osmolality (the principal stimulus for vasopressin secretion) to increase water retention to cope with the cardiovascular demands of pregnancy and lactation. Oxytocin and vasopressin secretion are determined by the action potential (spike) firing of magnocellular neurosecretory neurons of the hypothalamic supraoptic and paraventricular nuclei. In addition to synaptic input activity, spike firing depends on intrinsic excitability conferred by the suite of channels expressed by the neurons. Therefore, we analysed oxytocin and vasopressin neuron activity in anaesthetised non-pregnant, late-pregnant, and lactating rats to test the hypothesis that intrinsic excitability of oxytocin and vasopressin neurons is increased in late pregnancy and lactation to promote oxytocin and vasopressin secretion required for successful pregnancy and lactation. Hazard analysis of spike firing revealed a higher incidence of post-spike hyperexcitability immediately following each spike in oxytocin neurons, but not in vasopressin neurons, in late pregnancy and lactation, which is expected to facilitate high frequency firing during bursts. Despite lower osmolality in late-pregnant and lactating rats, vasopressin neuron activity was not different between non-pregnant, late-pregnant, and lactating rats, and blockade of osmosensitive ΔN-TRPV1 channels inhibited vasopressin neurons to a similar extent in non-pregnant, late-pregnant, and lactating rats. Furthermore, supraoptic nucleus ΔN-TRPV1 mRNA expression was not different between non-pregnant and late-pregnant rats, suggesting that sustained activity of ΔN-TRPV1 channels might maintain vasopressin neuron activity to increase water retention during pregnancy and lactation